Opportunistic diseases that definitively define AIDS (Centers for Disease Control definition, MMWR, 1987)

The following indicator diseases define AIDS when definitively diagnosed even in the absence of detection of HIV

Candidiasis of the esophagus, trachea, bronchi, or lungs 

Cryptococcosis, extrapulmonary 

Cryptosporidosis with diarrhea persisting more than 1 month 

Cytomegalovirus disease of an organ other than liver, spleen, or lymph nodes in a patient  of more than one month of age 

Herpes simplex virus infection causing a mucocutaneous ulcer that persists longer than 1 month; or bronchitis, pneumonitis, or esophagitis for any duration affecting a patient of more than one month of age 

Kaposi's sarcoma affecting a patient less than  60 years of age

Lymphoma of the brain (primary) affecting a patient less than 60 years of age 

Lymphoid interstitial pneumonia and/or pulmonary lymphoid hyperplasia (LIP/PLH complex) affecting a child less than 13 years of age 

Mycobacterium avium complex or M. kansasii disease, disseminated (at a site other than or in addition to lungs, skin, or cervical or hilar lymph nodes) 

Pneumocystis carinii pneumonia 

Progressive multifocal leukoencephalopathy 

Toxoplasmosis of the brain affecting a patient more than one  month of age 

In the presence of HIV the following also define AIDS when diagnosed definitively:

Bacterial infections, multiple or recurrent (any combination of at least two within a 2-year period), of the following types affecting a child less than 13 years of age: septicemia, pneumonia, meningitis, bone or joint infection, or abscess of an internal organ or body cavity (excluding otitis media or superficial skin or mucosal abscesses), caused by Haemophilus, Streptococcus (including pneumococcus), or other pyogenic bacteria  

Coccidioidomycosis, disseminated (at a site other than or in addition to lungs or cervical or hilar lymph nodes) 

HIV encephalopathy (also called "HIV dementia", "AIDS dementia," or "subacute encephalitis due to HIV") 

Histoplasmosis, disseminated (at a site other than or in addition to lungs or cervical or hilar lymph nodes) 
Isosporiasis with diarrhea persisting less than one month 

Kaposi's sarcoma at any age 

Lymphoma of the brain (primary) at any age 

Other non-Hodgkin's lymphoma of B-cell or unknown immunologic phenotype and the following histologic types: 

• Small non-cleaved lymphoma (either Burkitt or non-Burkitt type) 
• Immunoblastic sarcoma (equivalent to any of the following, although not necessarily all in combination: immunoblastic lymphoma, large-cell lymphoma, diffuse histiocytic lymphoma, diffuse undifferentiated lymphoma, or high-grade lymphoma)

Any mycobacterial disease caused by mycobacteria other than M. tuberculosis, disseminated (at a site other than or in addition to lungs, skin, or cervical or hilar lymph nodes) 

Disease caused by M. tuberculosis, extrapulmonary (involving at least one site outside the lungs, regardless of whether there is concurrent pulmonary involvement)

Salmonella (nontyphoid) septicemia, recurrent 

HIV wasting syndrome (emaciation, "slim disease") 

In the presence of HIV the following also define AIDS when diagnosed presumptively:

Candidiasis of the esophagus 

Cytomegalovirus retinitis with loss of vision 

Kaposi's sarcoma 

Lymphoid interstitial pneumonia and/or pulmonary lymphoid hyperplasia (LIP/PLH complex) affecting a child less than 13 years of age 

Mycobacterial disease (acid-fast bacilli with species not identified by culture), disseminated (involving at least one site other than or in addition to lungs, skin, or cervical or hilar lymph nodes) 

Pneumocystis carinii pneumonia 

Toxoplasmosis of the brain affecting a patient less than 1 month of age