MICROBIOLOGY AND IMMUNOLOGY ON-LINE

Hepatitis C is a flavivirus that causes non-A, non-B hepatitis. These are enveloped icosahedral positive strand RNA viruses with one primary translation product. This polyprotein is cleaved by a virally-encoded protease activity. Several inhibitors of the Hepatitis C protease have been developed which, in combination with RNA polymerase inhibitors, are very effect at curing the disease.

Among the Hepatits C NS3/4A serine protease inhibitors are:

Boceprevir - Merke (Brand name Victrelis) used in combination with peg-interferon a and ribavirin; withdrawn from market
Telaprevir - Johnson and Johnson/Vertex (Brand name Incivek) also used in combination with peg-interferon a and ribavirin; withdrawn from market
Simeprevir - Janssen (Brand name Olysio) also used in combination with peg-interferon a and ribavirin
Paritaprevir - AbbieVie
Grazoprevir - Merck
Glecaprevir - AbbieVie
Voxilaprevir - Gilead, marketed with Sofosbuvir and Velpatasvir as Epclusa

 

For further information on drugs used to treat Hepatitis C see this page